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desvenlafaxine will raise the level or effect of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Warning/Watch. Desvenlafaxine inhibits CYP2D6; with greater desvenlafaxine doses (ie, 400 mg) lower the CYP2D6 substrate dose by as many as fifty%; no dosage adjustment required with desvenlafaxine doses seven consecutive times straight away